- A techno-economic and environmental analysis for the production of biodiesel, ethanol, butanol, hydrogen and electricity as main products and acetone as by-product from oil palm was studied considering the biorefinery concept in the Colombian context. Fresh fruit bunches were used as raw material to obtain biofuels and bioenergy. As a result, the production costs under the biorefinery concept are 0.34, 9.59, 5.69, 6.98 and 5.69 USD per kilogram of biodiesel, hydrogen, butanol, ethanol and acetone, respectively. Besides, the cost related to the electricity generation is 0.7 USD per kWh. According to these results, biodiesel and hydrogen, have a positive economic margin of 77 and 20 %, respectively. On the other hand, the biorefinery presents a negative economic margin for both minimum and maximum sale prices of the products due to the low productivity of most of the process stages. As a consequence, the process scale is the key parameter in the economic profitability for this biorefinery. From the environmental point of view, the stages involved in the biodiesel production have a lesser extent of potential environmental impact in the biorefinery due to the minimum waste streams generated.